Key result
In patients with systemic lupus erythematosus without prior cardiovascular disease, higher SLE disease activity was significantly associated with an increased risk of ECG-4 abnormalities (HR 1.08).
Cross-Sectional (n=487)
No
Hazard Ratio: 1.08 (95% CI 1.02–1.16)
p-value: p=0.009
Resting ECG abnormalities are highly prevalent in SLE patients without known cardiovascular disease and are associated with older age, active disease, and organ damage, suggesting ECG could be a useful screening tool for CVD risk in this population.
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SLE activity may flag subclinical cardiac risk on ECG; leaves open whether screening alters outcomes in lupus.
Rayes et al. (2017) conducted a cross-sectional in Systemic lupus erythematosus (SLE) without cardiovascular disease (n=487). SLE disease activity (Adjusted mean SLEDAI-2K) vs. Lower SLE disease activity was evaluated on Association of SLE disease activity (AMS 2 years prior) with ECG-4 abnormalities (HR 1.08, 95% CI 1.02-1.16, p=0.009). In patients with systemic lupus erythematosus without prior cardiovascular disease, higher SLE disease activity was significantly associated with an increased risk of ECG-4 abnormalities (HR 1.08).
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