Temporal Subtraction of Thin-Section Thoracic Computed Tomography Based on a 3-Dimensional Nonlinear Geometric Warping Technique

The authors developed a computer system that automatically produces temporal subtraction images on thin-section thoracic computed tomography based on a 3-dimensional nonlinear geometric warping technique. The automated subtraction system was applied to data from 20 subjects with lung diseases. Nineteen (95%) of 20 results showed good or excellent image quality. The remaining 1 (5%) showed adequate image quality. Our preliminary computer system demonstrates the potential for a clinically useful automated subtraction system.