Key result
Nonalcoholic fatty liver disease was significantly associated with decreased flow-mediated dilatation compared to controls (OR 1.612), with grade 3 steatosis being the strongest predictor of endothelial dysfunction.
Why the study?
Does the presence and severity of NAFLD correlate with impaired flow-mediated dilatation in patients without known cardiovascular disease?
Cross-Sectional (n=266)
No
Does the presence and severity of NAFLD correlate with impaired flow-mediated dilatation in patients without known cardiovascular disease?
Odds Ratio: 1.612 (95% CI 1.296–2.005)
Absolute Event Rate: 72.2% vs 41.1%
p-value: p=<0.001
The severity of hepatic steatosis in NAFLD is strongly associated with endothelial dysfunction, suggesting an increased early atherosclerotic risk in these patients.
May signal higher early atherosclerotic risk in severe NAFLD; hypothesis-generating and requires prospective validation.
It is shown that there are strong associations between nonalcoholic fatty liver disease (NAFLD) and endothelial dysfunction. The aim of our study was to reveal whether steatosis or fibrosis score is more important in the development of endothelial dysfunction in patients with NAFLD in a prospective manner.This cross-sectional study included 266 subjects. These subjects were divided into 2 groups depending on presence of hepatosteatosis sonographically. Patients with hepatosteatosis were also divided into 3 subgroups depending on degree of steatosis: grade 1, 2, and 3. In all patients, Aspartate aminotransferase-to-Platelet Ratio Index and Fibrosis-4 (FIB4) scores were calculated. In addition, flow-mediated dilatation (FMD) measurements were recorded.There was NAFLD in 176 (66.2%) of 266 patients included. There were no significant differences in sex and age distributions between patients with NAFLD (group 1) and controls without NAFLD (group 2) (P = 0.05). Mean Aspartate aminotransferase-to-Platelet Ratio Index score was significantly higher in group 1 compared with the control group (P = 0.001), whereas no significant difference was detected regarding FIB4 scores between groups (P = 0.4). Mean FMD value was found to be significantly lower in group 1 (P = 0.008). Patients with grade 3 hepatosteatosis had significantly lower FMD values than those with grade 1 steatosis and controls (P = 0.001). In univariate and multivariate analyses in group 1, no significant difference was detected regarding mean FMD measurements (P = 0.03). Again, no significant difference was detected in mean FMD measurement between FIB4 subgroups among patients with NAFLD and the whole study group (P = 0.09).The endothelial dysfunction is associated with steatosis in patients with NAFLD.
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Sapmaz et al. (2016) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=266). Nonalcoholic fatty liver disease (NAFLD) vs. Normal hepatic ultrasonography (without NAFLD) was evaluated on Decreased flow-mediated dilatation (<10%) (OR 1.612, 95% CI 1.296-2.005, p=<0.001). Nonalcoholic fatty liver disease was significantly associated with decreased flow-mediated dilatation compared to controls (OR 1.612), with grade 3 steatosis being the strongest predictor of endothelial dysfunction.
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