Key result
A bibliometric analysis of 898 articles identified three main research clusters focusing on miRNAs in obesity-associated diseases, adipogenesis regulation, and brown adipose tissue thermogenesis.
Why the study?
Despite the relevance of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject had been performed.
This bibliometric analysis maps the research landscape of miRNAs in obesity, highlighting their potential as biomarkers and therapeutic targets for obesity-associated diseases including cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Maps miRNA research clusters in obesity; leaves open translation to biomarkers or therapies for cardiovascular disease.
Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases.
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Alves et al. (2019) studied Obesity, adipose tissue, and microRNAs (n=898). Bibliometric analysis was evaluated on Keyword clusters and research trends. A bibliometric analysis of 898 articles identified three main research clusters focusing on miRNAs in obesity-associated diseases, adipogenesis regulation, and brown adipose tissue thermogenesis.
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