Key result
MicroRNAs act as oncogenes and tumor suppressors in obesity-related malignancies, offering prognostic and therapeutic potential.
Why the study?
MicroRNAs play crucial roles in regulating gene expression related to obesity and cancer, but their complex mechanisms and therapeutic potential in obesity-related malignancies require clarification.
Design
Review
Authors
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miRNAs' dual roles in obesity and cancer are hypothesis-generating; leaves open therapeutic targeting pending validation studies.
This review summarizes the complex mechanisms by which miRNAs govern adipogenesis, cancer, and metabolic dysregulation, highlighting their potential as therapeutic targets and biomarkers in obesity-related malignancies.
Doghish et al. (2025) conducted a review in Obesity and cancer. MicroRNAs (miRNAs) was evaluated. MicroRNAs play a crucial dual role as oncogenes and tumor suppressors in obesity-related malignancies, offering potential as prognostic markers and therapeutic targets.
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