Acquired Dysgammaglobulinemia

THE immune globulins can be separated into three classes on the basis of their electrophoretic and ultracentrifugal properties.1 The largest group is the gamma2 globulin, which sediments in the ultracentrifuge with a sedimentation constant of 7 Svedbergs (7S). Two minor components of the immune globulins both have gamma1-globulin mobility but are distinguished by the fact that they have either 7S or 19S sedimentation constants. In congenital and acquired agammaglobulinemia all three classes of immune globulin are absent from the serum.2 A number of male children have been described in whose serum virtually no 7S gamma globulin is . . .