Key result
Peptide-based fluoromethyl ketones significantly reduced rhinovirus multiplication in cell culture and inhibited the activity of picornaviral 2A proteinases.
Peptide-based fluoromethyl ketones, traditionally known as caspase inhibitors, also demonstrate antiviral activity by inhibiting picornaviral 2A proteinases and reducing rhinovirus multiplication.
May support repurposing caspase inhibitors as antivirals; leaves open clinical translation pending in vivo validation.
Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases.
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Deszcz et al. (2004) studied Rhinovirus infection. Peptide-based fluoromethyl ketones (caspase inhibitors) was evaluated on Rhinovirus multiplication and picornaviral 2A proteinase activity. Peptide-based fluoromethyl ketones significantly reduced rhinovirus multiplication in cell culture and inhibited the activity of picornaviral 2A proteinases.
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