What is the clinical evidence from this study?

Population: Picornavirus infections (human rhinovirus, coxsackievirus, mengovirus). Intervention: Zinc ionophores (pyrithione and hinokitiol). Primary outcome: Inhibition of picornavirus multiplication and viral polyprotein processing.

October 16, 2008Journal of Virology

Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

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Key result

Zinc ionophores pyrithione and hinokitiol efficiently inhibited human rhinovirus, coxsackievirus, and mengovirus multiplication by importing extracellular zinc ions and interfering with viral polyprotein processing.

Why the study?

Do zinc ionophores pyrithione and hinokitiol inhibit picornavirus multiplication in vitro?

Key Points

This research aims to evaluate the antiviral activity of pyrithione and hinokitiol against picornavirus infections by examining their effects on viral replication mechanisms.
Identified pyrithione and hinokitiol as inhibitors of human rhinovirus, coxsackievirus, and mengovirus multiplication.
Analyzed the cleavage of eIF4GI by rhinoviral 2A protease in the presence of the compounds.
Observed the import of zinc ions into cells and their localization within punctate structures and mitochondria.
Pyrithione and hinokitiol effectively inhibit picornavirus replication by disrupting viral polyprotein processing.
Cleavage of eIF4GI by rhinoviral protease was completely inhibited in the presence of the compounds.
Zinc import was shown to be critical for the antiviral activity, requiring continuous presence of the zinc ionophores to be effective.

Structured PICO

Do zinc ionophores pyrithione and hinokitiol inhibit picornavirus multiplication in vitro?

Population

In vitro models of picornavirus infection (human rhinovirus, coxsackievirus, and mengovirus)

Intervention

Zinc ionophores pyrithione (PT) and hinokitiol (HK)

Outcome

Inhibition of virus multiplication and mechanism of action (cleavage of eIF4GI, viral polyprotein processing, zinc import)surrogate

Zinc ionophores pyrithione and hinokitiol inhibit picornavirus replication by increasing intracellular zinc levels, which interferes with viral polyprotein processing.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports preclinical testing in picornavirus myocarditis models; leaves open clinical translation.

Cite This Study

Krenn et al. (2008) studied Picornavirus infections (human rhinovirus, coxsackievirus, mengovirus). Zinc ionophores (pyrithione and hinokitiol) was evaluated on Inhibition of picornavirus multiplication and viral polyprotein processing. Zinc ionophores pyrithione and hinokitiol efficiently inhibited human rhinovirus, coxsackievirus, and mengovirus multiplication by importing extracellular zinc ions and interfering with viral polyprotein processing.

synapsesocial.com/papers/6a5cf8aba170fefb8e89f715 https://doi.org/10.1128/jvi.01543-08

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Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider