May 1, 1985Journal of VirologyOpen Access

Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro

View Full Paper

Ask AI

Bookmark

Population

HeLa cells in tissue culture

Design

Preclinical

Authors

DED EtchisonUniversity of California, Irvine SFS Fout

Discussion

Member takes

Implication

Does not yet alter rhinovirus management; extends poliovirus-like translation shutoff mechanism to HRV14 in cell models.

Structured PICO

Population

HeLa cells in tissue culture

Intervention

Human rhinovirus 14 infection

Outcome

Proteolytic cleavage of the Mr 220,000 subunit of the cap-binding protein complex and inhibition of host cell translationsurrogate

Human rhinovirus 14 inhibits host cell translation through a mechanism similar to poliovirus, involving cleavage of the p220 cap-binding complex subunit.

Cite This Study

Etchison et al. (1985) studied this question.

synapsesocial.com/papers/6a8d05fcd190ea52f78e4d98 https://doi.org/10.1128/jvi.54.2.634-638.1985

View Full Paper

Ask AI

Bookmark

Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider