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This basic science study identifies the specific cleavage site of HRV2 2A proteinase in eIF4GII, providing molecular insights into how picornaviruses shut down host cellular protein synthesis.
Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP).
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Gradi et al. (2003) studied this question.
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