The Processing of eIF4GI by Human Rhinovirus Type 2 2A pro : Relationship to Self-Cleavage and Role of Zinc
Population
In vitro models studying human rhinovirus type 2 2A proteinase (HRV2 2A)
Comparison
Zinc chelator or specific mutation preventing… vs Wild-type HRV2 2A(pro) or absence of zinc chelator
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Zinc chelation may inhibit HRV 2A(pro); hypothesis-generating for antivirals and leaves open in vivo efficacy before any clinical consideration.
Structured PICO
P
Population
In vitro models (rabbit reticulocyte lysates and HeLa cells) studying human rhinovirus type 2 2A proteinase (HRV2 2A(pro))
I
Intervention
Zinc chelator or specific mutation preventing self-processing between VP1 and 2A(pro)
C
Comparator
Wild-type HRV2 2A(pro) or absence of zinc chelator
O
Outcome
eIF4GI cleavage and self-processing activitysurrogate
Self-processing of HRV2 2A(pro) is required for eIF4GI cleavage, and zinc is essential for its enzymatic activity, suggesting zinc chelation as a potential antiviral strategy.
Cite This Study
Glaser et al. (2003) studied this question.