Population
In vitro translation system using human eIF4G and recombinant 2A proteases from human coxsackievirus…
Comparison
Site-directed mutagenesis replacing one amino… vs Wild-type eIF4G
Design
Preclinical
Authors
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Bolsters eIF4G cleavage as a key viral mechanism; hypothesis-generating for host-directed antivirals pending in vivo validation.
A single amino acid mutation in eIF4G confers resistance to picornaviral 2A proteases, supporting the model that these proteases inhibit cap-dependent translation via direct eIF4G proteolysis.
Lamphear et al. (1996) studied this question.
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