Population
Recombinant eIF4G purified from Sf9 insect cells
Comparison
Purified rhinovirus 2A proteinase (2Apro) vs eIF4G alone versus eIF4G-eIF4E complex
Design
Preclinical
Authors
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Prioritizes eIF4G-eIF4E for rhinovirus antiviral targeting; extends mechanistic models but leaves open human translation.
The study demonstrates that the eIF4G-eIF4E complex, rather than eIF4G alone, is the preferred substrate for direct cleavage by rhinovirus 2A proteinase.
Haghighat et al. (1996) studied this question.
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