Population
HeLa cells and reticulocyte lysate
Comparison
Characterization of eIF4GII vs eIF4GI
Design
Preclinical
Authors
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Identifies eIF4GII as functional homolog; leaves open in vivo roles in mammalian translation and viral shutoff.
The discovery of eIF4GII as a functional homolog of eIF4GI provides insights into mammalian translation initiation and the mechanism of host protein synthesis shutoff following picornavirus infection.
Gradi et al. (1998) studied this question.
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