September 1, 1995Molecular and Cellular BiologyOpen Access

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

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Population

Molecular models of eukaryotic translation initiation factor 4E, eIF-4 gamma, and 4E-binding proteins

Comparison

Deletion mutants and point mutations in the… vs Wild-type sequences

Design

Preclinical

Authors

SMSylvie MaderInstitute for Research in Immunology and Cancer HLHan LeeMassachusetts General Hospital APArnim PauseInstitute for Research in Immunology and Cancer

Discussion

Member takes

Implication

Advances molecular understanding of translation; leaves open any cardiovascular applications.

Structured PICO

Population

Molecular models of eukaryotic translation initiation factor 4E (eIF-4E), eIF-4 gamma, and 4E-binding proteins (4E-BPs)

Intervention

Deletion mutants and point mutations in the binding regions

Comparator

Wild-type sequences

Outcome

Molecular interactions between eIF-4E and eIF-4 gamma or 4E-BPs

Identifies a conserved binding motif shared by eIF-4 gamma and 4E-BPs that is critical for interaction with eIF-4E, providing insight into the mechanisms of translational regulation.

Cite This Study

Mader et al. (1995) studied this question.

synapsesocial.com/papers/6a7e0d171ec832c82ccdbdf1 https://doi.org/10.1128/mcb.15.9.4990

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The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider