Why the study?
Does pyrrolidine dithiocarbamate reduce viral production and promote cell survival in cell cultures infected with human rhinoviruses?
Population
Cell culture infected with human rhinoviruses (HRVs) and poliovirus
Comparison
Pyrrolidine dithiocarbamate (PDTC) vs Other antioxidants or untreated infected cells
Design
Preclinical
Authors
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PDTC shows anti-HRV activity in cell culture; leaves open translation to in vivo or clinical settings.
Does pyrrolidine dithiocarbamate reduce viral production and promote cell survival in cell cultures infected with human rhinoviruses?
PDTC demonstrates potent antiviral activity against human rhinoviruses and poliovirus in cell culture by inhibiting viral protein synthesis.
Gaudernak et al. (2002) studied this question.
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