Key result
Pyrrolidine dithiocarbamate (PDTC) inhibits the replication of coxsackievirus B3 and mengovirus by transporting zinc ions into cells and disturbing viral RNA synthesis and polyprotein processing.
Population
Cells infected with coxsackievirus B3 (CVB3) or mengovirus
Design
Preclinical
Authors
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Preclinical data only; leaves open whether zinc ionophores can be developed into therapies for human picornavirus infections.
PDTC inhibits picornavirus replication through zinc ion transport, though the specific mechanism of polyprotein processing interference differs between enteroviruses and cardioviruses.
Lanke et al. (2007) studied Picornavirus infection (coxsackievirus B3 and mengovirus). Pyrrolidine dithiocarbamate (PDTC) was evaluated on Viral replication and polyprotein processing. Pyrrolidine dithiocarbamate (PDTC) inhibits the replication of coxsackievirus B3 and mengovirus by transporting zinc ions into cells and disturbing viral RNA synthesis and polyprotein processing.
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