What question did this study set out to answer?

To assess whether early exposure to mercury from thimerosal-containing vaccines and immune globulin preparations is associated with neuropsychological deficits in children aged 7 to 10 years.

September 26, 2007New England Journal of MedicineOpen Access

Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years

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Authors

WTW. Thompson CPCristofer Price BGBarbara Goodson

Discussion

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Overview

Cohort study finds no causal association between early thimerosal exposure and neuropsychological deficits in children aged 7 to 10 years, suggesting early vaccine preservatives are safe.

Key Points

To assess whether early exposure to mercury from thimerosal-containing vaccines and immune globulin preparations is associated with neuropsychological deficits in children aged 7 to 10 years.
Enrolled 1047 children aged 7 to 10 years and administered standardized tests evaluating 42 neuropsychological outcomes, excluding autism-spectrum disorders.
Quantified thimerosal-derived mercury exposure prenatally, neonatally (birth to 28 days), and during the first 7 months of life using computerized records, medical charts, personal immunization logs, and parent interviews.
Identified only a few statistically significant associations with thimerosal exposure across 42 neuropsychological measures, with effects being small and evenly divided between positive and negative directions.
Higher prenatal mercury exposure correlated with superior language scores but poorer attention and executive functioning; neonatal exposure was linked to poorer speech articulation and improved fine motor coordination; exposure from birth to 7 months was associated with better fine motor skills and attention/executive functioning.

Cite This Study

Thompson et al. (2007) studied this question.

synapsesocial.com/papers/6a89751f502e90db6771a00f https://doi.org/10.1056/nejmoa071434

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September 26, 2007New England Journal of MedicineOpen Access

Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years

View Full Paper

Ask AI

Bookmark

Authors

WTW. Thompson CPCristofer Price BGBarbara Goodson

Discussion

Member takes

Overview

Cohort study finds no causal association between early thimerosal exposure and neuropsychological deficits in children aged 7 to 10 years, suggesting early vaccine preservatives are safe.

Key Points

To assess whether early exposure to mercury from thimerosal-containing vaccines and immune globulin preparations is associated with neuropsychological deficits in children aged 7 to 10 years.
Enrolled 1047 children aged 7 to 10 years and administered standardized tests evaluating 42 neuropsychological outcomes, excluding autism-spectrum disorders.
Quantified thimerosal-derived mercury exposure prenatally, neonatally (birth to 28 days), and during the first 7 months of life using computerized records, medical charts, personal immunization logs, and parent interviews.
Identified only a few statistically significant associations with thimerosal exposure across 42 neuropsychological measures, with effects being small and evenly divided between positive and negative directions.
Higher prenatal mercury exposure correlated with superior language scores but poorer attention and executive functioning; neonatal exposure was linked to poorer speech articulation and improved fine motor coordination; exposure from birth to 7 months was associated with better fine motor skills and attention/executive functioning.

Cite This Study

Thompson et al. (2007) studied this question.

synapsesocial.com/papers/6a89751f502e90db6771a00f https://doi.org/10.1056/nejmoa071434

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