What question did this study set out to answer?

To determine the diagnostic utility of incorporating clinical history and follow-up vascular imaging when evaluating cerebral and cervical arteriopathy in children presenting with arterial ischemic stroke.

November 11, 2014StrokeOpen Access

Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke

View Full Paper

Ask AI

Bookmark

Authors

MWMax WintermarkNorthwestern University NHNancy K. HillsUniversity of California, San Francisco GDGabrielle deVeberUniversity of Toronto

Discussion

Member takes

Implication

Prospective cohort study shows clinical data and follow-up imaging improve arteriopathy detection in pediatric stroke, indicating persistent diagnostic challenges.

Key Points

To determine the diagnostic utility of incorporating clinical history and follow-up vascular imaging when evaluating cerebral and cervical arteriopathy in children presenting with arterial ischemic stroke.
Conducted an international prospective cohort study across 39 centers enrolling 355 children (aged 29 days to 18 years) with arterial ischemic stroke and mandatory baseline vascular imaging.
A stroke neurologist and neuroradiologist independently assessed vascular imaging across three sequential steps: baseline imaging alone, addition of clinical data, and addition of follow-up vascular imaging, with disagreements adjudicated by committee.
Adjudicated gold-standard diagnoses established definite arteriopathy in 36% (n=127), possible arteriopathy in 9.6% (n=34), and absent arteriopathy in 55% (n=194) of participants.
Diagnostic sensitivity progressively increased across evaluation steps from 79% with baseline imaging alone, to 90% with clinical data, and 94% with follow-up imaging.
Diagnostic specificity remained consistently high across all three steps (99%, 100%, and 100%), alongside robust inter-reviewer agreement (kappa = 0.77, 0.81, and 0.78).

Cite This Study

Wintermark et al. (2014) studied this question.

synapsesocial.com/papers/6a8975ec65b7d5248dc124eb https://doi.org/10.1161/strokeaha.114.007404

View Full Paper

Ask AI

Bookmark

Implication

Prospective cohort study shows clinical data and follow-up imaging improve arteriopathy detection in pediatric stroke, indicating persistent diagnostic challenges.

Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider