Celecoxib-Induced Cholestatic Hepatitis

Letters6 February 2001Celecoxib-Induced Cholestatic HepatitisMark V. Galan, MD, Stuart C. Gordon, MD, and Ann L. Silverman, MDMark V. Galan, MDWilliam Beaumont Hospital; Royal Oak, MI 48073-6769 (Galan, Gordon, Silverman), Stuart C. Gordon, MDWilliam Beaumont Hospital; Royal Oak, MI 48073-6769 (Galan, Gordon, Silverman), and Ann L. Silverman, MDWilliam Beaumont Hospital; Royal Oak, MI 48073-6769 (Galan, Gordon, Silverman)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 55-year-old nonalcoholic obese woman who was allergic to sulfa presented with a 5-day history of jaundice, malaise, and pruritic rash that began 3 weeks after she took celecoxib, 200 mg/d, for radiculopathy-associated pain.The patient's medical history included type 2 diabetes mellitus, hypertension, hyperlipidemia, and chronic lymphocytic leukemia, all of which were stable at presentation. Long-standing medications included indapamide, conjugated estrogens, glyburide, and atorvastatin. The patient had stopped taking celecoxib 5 days before hospitalization.Physical examination showed jaundice and a diffuse maculopapular, erythematous rash on the upper abdomen, back, and chest. The abdomen was diffusely tender ...References1. Dujovne CA, Chan CH, Zimmerman HJ. Sulfonamide hepatic injury. Review of the literature and report of a case due to sulfamethoxazole. N Engl J Med. 1967;277:785-8. CrossrefMedlineGoogle Scholar2. Kowdley KV, Keeffe EB, Fawaz KA. Prolonged cholestasis due to trimethoprim sulfamethoxazole. Gastroenterology. 1992;102:2148-50. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mark V. Galan, MD; Stuart C. Gordon, MD; Ann L. Silverman, MDAffiliations: William Beaumont Hospital; Royal Oak, MI 48073-6769 (Galan, Gordon, Silverman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCelecoxib-Induced Cholestatic Hepatotoxicity in a Patient with Cirrhosis Paulo Alegria , Luís Lebre , and Cristina Chagas Metrics Cited byTransplantation of adipose-derived mesenchymal stem cells ameliorates acute hepatic injury caused by nonsteroidal anti-inflammatory drug diclofenac sodium in female ratsLiver Injury Induced by the Interaction Between Fluoxetine and Celecoxib: A Case Report and the Literature ReviewA case of acute liver failure induced by Pregabalin and CelecoxibCelecoxib-induced Liver InjuryDrugs and ToxinsHepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled TrialsHepatotoxicity induced by coxibs: how concerned should we be?CelecoxibApplication of urine proteomics for biomarker discovery in drug-induced liver injuryA case of drug-induced liver injury by celecoxibSulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor AntagonistsHepatic injury due to drugs, herbal compounds, chemicals and toxinsDrug-Induced Liver InjuryIncreased risk of hospitalization for acute hepatitis in patients with previous exposure to NSAIDsNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)Late-onset celecoxib-induced combined hepato-nephrotoxicityLiver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compoundClinical pharmacology of celecoxib, a COX-2 selective inhibitorProstaglandin I2 and E2 mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injuryCelecoxibProlonged cholestasis associated with short-term use of celecoxibHepatotoxicidad secundaria a fármacos de uso comúnSulfonamide Cross-Reactivity: Fact or Fiction?Cutaneous vasculitis induced by cyclo-oxygenase-2 selective inhibitorsAdverse hepatic drug reactions: inflammatory episodes as consequence and contributorSevere Cholestasis and Acute Renal Failure Related to RofecoxibA rare case of Rofecoxib-induced cholestatic hepatitisHepatotoxicity associated with non-steroidal anti-inflammatory drugsDrug-induced cholestasisPharmacology and Clinical action of Cox-2 Selective NsaidsAnti-inflammatory and antipyretic analgesics and drugs used in goutAcute Cholestatic Hepatitis Associated with CelecoxibRofecoxib-induced cholestatic hepatitis: treatment with molecular adsorbent recycling system (MARS)Celecoxib-Induced Cholestatic Hepatotoxicity in a Patient with CirrhosisPaulo Alegria, MD, Luís Lebre, MD, and Cristina Chagas, MDFever: beneficial and detrimental effects of antipyreticsDrug-induced liver diseaseCholestatic syndromesCox-2 Inhibitors: Today and TomorrowBeneficios y riesgos de los antiinflamatorios no esteroides inhibidores selectivos de la ciclooxigenasa-2A Protective Role for Cyclooxygenase-2 in Drug-Induced Liver Injury in MiceCelecoxib 6 February 2001Volume 134, Issue 3Page: 254KeywordsBilirubinDrugsEosinophiliaEstrogensHepatitisHepatitis ALiverRashesResearch laboratoriesUltrasound imaging ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. 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