Deoxyribonucleic Acid Ploidy Enhances the Cytological Prediction of Recurrent Transitional Cell Carcinoma of the Bladder

No AccessJournal of UrologyClinical Urology: Original Articles1 Sep 1997Deoxyribonucleic Acid Ploidy Enhances the Cytological Prediction of Recurrent Transitional Cell Carcinoma of the Bladder Joel W. Slaton, Colin P.N. Dinney, Robert W. Veltri, M. Craig Miller, Monica Liebert, Gerard J. O'Dowd, and H. Barton Grossman Joel W. SlatonJoel W. Slaton , Colin P.N. DinneyColin P.N. Dinney , Robert W. VeltriRobert W. Veltri , M. Craig MillerM. Craig Miller , Monica LiebertMonica Liebert , Gerard J. O'DowdGerard J. O'Dowd , and H. Barton GrossmanH. Barton Grossman View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64322-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether deoxyribonucleic acid (DNA) ploidy analysis by image analysis cytometry enhances the cytological diagnosis of recurrent transitional cell carcinoma of the bladder. Materials and Methods: A retrospective study was performed during a 5-year period to evaluate the cytological diagnosis and DNA ploidy analysis of 469 patients with previously diagnosed superficial transitional cell carcinoma. Cytological and DNA ploidy analysis was performed on 1,034 urine and bladder wash specimens, and the patients were monitored with cystoscopy and biopsies as clinically indicated. Cytology results were classified as normal, atypical, dysplastic or cancerous, and DNA ploidy was defined as normal if the diploid index was 1.2 or less, the S phase - G2M fraction was less than 21% or if there were 3% or less hyperploid cells, or abnormal if there was an increased S phase - G2M fraction, an aneuploid peak on the histogram or tetraploidy or hyperploidy was present. Results: The majority of patients (85 of 88, 97%) with a cytological diagnosis of cancer had an abnormal DNA ploidy, and in 60 of 85 of these patients (71%) recurrence was diagnosed within 6 months. 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Anderson Cancer Center, Houston, Texas, and UroCor, Inc., Oklahoma City, Oklahoma.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byHALLING K, KING W, SOKOLOVA I, KARNES R, MEYER R, POWELL E, SEBO T, CHEVILLE J, CLAYTON A, KRAJNIK K, EBERT T, NELSON R, BURKHARDT H, RAMAKUMAR S, STEWART C, PANKRATZ V, LIEBER M, BLUTE M, ZINCKE H, SEELIG S, JENKINS R and O’KANE D (2018) A Comparison of BTA Stat, Hemoglobin Dipstick, Telomerase and Vysis Urovysion Assays for the Detection of Urothelial Carcinoma in UrineJournal of Urology, VOL. 167, NO. 5, (2001-2006), Online publication date: 1-May-2002.JUNG I, REEDER J, COX C, SIDDIQUI J, O’CONNELL M, COLLINS L, YANG Z, MESSING E and WHEELESS L (2018) CHROMOSOME 9 MONOSOMY BY FLUORESCENCE IN SITU HYBRIDIZATION OF BLADDER IRRIGATION SPECIMENS IS PREDICTIVE OF TUMOR RECURRENCEJournal of Urology, VOL. 162, NO. 6, (1900-1903), Online publication date: 1-Dec-1999. Volume 158Issue 3September 1997Page: 806-811 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Joel W. Slaton More articles by this author Colin P.N. Dinney More articles by this author Robert W. Veltri More articles by this author M. Craig Miller More articles by this author Monica Liebert More articles by this author Gerard J. O'Dowd More articles by this author H. Barton Grossman More articles by this author Expand All Advertisement PDF downloadLoading ...