The effect of influenza vaccine on cytokine production by human mononuclear cells

Background: Seasonal influenza outbursts present a considerable challenge for health providers. Therefore, great efforts are made to vaccinate as many individuals as possible to avoid loss of labor days, unnecessary admissions and complications. The vaccine used in our country during the 2014-2015 seasons contains the following influenza strains, i.e., A/California (H1N1), A/Texas (H3N2) and B/Massachusetts. Vaccinated people react by mobilizing all components of the immune system. The aim of the study was to examine the vaccine effect on human peripheral blood mononuclear cells (PBMC) activation and their capacity for inflammatory cytokine production.