Key result
The 99th percentile upper reference limit for cTnT in healthy Chinese children was 38 ng/L for ages 1-<4 months, 26 ng/L for 4-12 months, and 12 ng/L for 1-18 years.
Why the study?
Clinical use of cTnT assays has historically been limited to adults despite growing routine use and recognized value in pediatric cardiology, leaving a need for normative values in children.
What are the normative age-specific 99th percentile upper reference limits for the 5th generation cardiac troponin T assay in healthy Chinese children?
Cross-Sectional (n=1,280)
What are the normative age-specific 99th percentile upper reference limits for the 5th generation cardiac troponin T assay in healthy Chinese children?
Provides age-specific 99th percentile upper reference limits for the 5th generation cardiac troponin T assay in Chinese children, facilitating accurate diagnosis of myocardial injury in pediatric populations.
May aid cTnT interpretation in Chinese children; hypothesis-generating and requires prospective validation before clinical adoption.
The clinical use of the cardiac troponin T (cTnT) assay was limited to the adult population in the diagnosis and prognosis of myocardial injury. However, emerging studies indicated its significant value in the assessment of pediatric cardiology, and it has been routinely measured in most hospitals. Our study investigated the normative values of cTnT in Chinese children and reported the age-specific 99th percentile cut-off for them.A total of 1280 apparently healthy Chinese children were enrolled in our study. Serum levels of cTnT were analyzed on the Roche Elecsys Troponin T Gen 5 STAT assay. According to the Clinical and Laboratory Standards Institute C28-A3 guideline, the 99th percentile upper reference limits (URLs) with 90% confidence intervals (CIs) were calculated in different age subgroups.The 99th percentile URL was 38 (90%CI: 37.0-51.0) ng/L for 1 to <4months old, 26 (90%CI: 25.2-28.5) ng/L for 4 to ≤ 12months old, and 12 (90%CI: 11.1-12.9) ng/L for 1 to 18 years old, respectively. For subjects aged from 1 to 18years, boys had slightly higher cTnT levels than girls (P = .003), while our assay could not measure low cTnT concentrations (≥the limit of detection) in 50% girls.Our study provided age-specific URLs of cTnT for Chinese children, with the 5th generation cTnT assay from Roche Diagnostics. It had significant clinical implications in the interpretation and use of test results for pediatric cardiology.
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A 2022 study conducted a cross-sectional in Healthy (n=1,280). Cardiac troponin T (cTnT) testing was evaluated on 99th percentile upper reference limits (URLs) of cTnT. The 99th percentile upper reference limit for cTnT in healthy Chinese children was 38 ng/L for ages 1-<4 months, 26 ng/L for 4-12 months, and 12 ng/L for 1-18 years.
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