What question did this study set out to answer?

To determine the metabolic impact of prolonged testosterone propionate administration on body weight, electrolyte balance, water retention, and energy expenditure in eunuchoid patients.

August 1, 1938Endocrinology

The Effect of Testosterone Propionate on Nitrogen, Electrolyte, Water and Energy Metabolism in Eunuchoidism1

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Authors

AKAllan T. KenyonUniversity of Chicago ISIrene SandifordUniversity of Minnesota HBHUGHES A. BRYANUniversity of Chicago

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Implication

Interventional study demonstrates rapid weight gain and fluid retention in eunuchoid patients, indicating both water accumulation and anabolic tissue growth.

Key Points

To determine the metabolic impact of prolonged testosterone propionate administration on body weight, electrolyte balance, water retention, and energy expenditure in eunuchoid patients.
Monitored body weight, clinical symptoms of water retention, and food intake in four eunuchoid patients receiving prolonged testosterone propionate therapy.
Assessed resting oxygen consumption via basal metabolic rate (BMR) during therapy in one patient.
Body weight increased by 1.5 to 2.0 kg within 10 days and reached 4.5 to 8.5 kg over 28 to 64 days across all four patients.
Weight gain was accompanied by facial fullness in all four patients, peripheral edema in two patients, and increased food intake in two patients.
Discontinuing or lowering the dosage led to rapid partial weight loss in three patients, while one patient sustained the gain, alongside a slight rise in basal metabolic rate in the single patient tested.

Cite This Study

Kenyon et al. (1938) studied this question.

synapsesocial.com/papers/6a897acc7fec28afabc11b16 https://doi.org/10.1210/endo-23-2-135

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Implication

Interventional study demonstrates rapid weight gain and fluid retention in eunuchoid patients, indicating both water accumulation and anabolic tissue growth.

The Effect of Testosterone Propionate on Nitrogen, Electrolyte, Water and Energy Metabolism in Eunuchoidism1

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of Testosterone Propionate on Nitrogen, Electrolyte, Water and Energy Metabolism in Eunuchoidism1

Discussion

Member takes

Implication

Key Points

Cite This Study

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