Why the study?
Does the method of calculating the time constant of left ventricular isovolumic relaxation (tau) affect its dependence on pericardial pressure in an animal model?
Population
8 closed-chest anesthetized dogs
Design
Preclinical
Authors
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Weiss tau may reflect pericardial pressure rather than LV relaxation; leaves open optimal tau calculation for clinical diastolic assessment.
Does the method of calculating the time constant of left ventricular isovolumic relaxation (tau) affect its dependence on pericardial pressure in an animal model?
Changes in the value of tau calculated from intracavitary LV pressure by the method of Weiss et al may reflect changes in pericardial pressure rather than true changes in LV diastolic function.
Frais et al. (1990) studied this question.
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