Population
12 rabbits (6 control, 6 cholesterol-fed)
Comparison
1% cholesterol diet for 8 weeks vs Control diet
Design
Preclinical
Follow-up
8 weeks
Authors
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Local ET-1 upregulation may contribute to atherosclerosis progression; leaves open whether ECE inhibition alters disease in vivo.
Local vascular wall ET-1 and ECE immunoreactivity are increased in early experimental atherosclerosis, suggesting a role in the local generation of ET-1 and disease progression.
Grantham et al. (1998) studied this question.
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