Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1966Japanese Heart JournalOpen Access

Effects of Nitroglycerin on H3-Catecholamine Metabolism

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does nitroglycerin accelerate the inactivation of catecholamines in patients and animal models?

Population

18 patients (including 6 cases with angina pectoris) and 6 rabbits.

Comparison

Nitroglycerin administered sublingually during… vs Patients without nitroglycerin treatment and…

Design

Other

Follow-up

Up to 6 hours post-infusion

Authors

TKTachio KobayashiTokyo Medical UniversityTKTerutomo KajiharaUniversity of Tokyo HospitalHOHirofumi OsadaChubu University

Discussion

Loading...

Member takes

Implication

May support metabolic catecholamine inactivation by nitroglycerin; leaves open contribution to anti-anginal effects beyond vasodilation.

Structured PICO

Does nitroglycerin accelerate the inactivation of catecholamines in patients and animal models?

P
Population
18 patients (including 6 cases with angina pectoris) and 6 rabbits.
I
Intervention
Nitroglycerin administered sublingually during infusion of H3-epinephrine or H3-norepinephrine (0.15μg/Kg/min for 30 to 60 min).
C
Comparator
Patients without nitroglycerin treatment and non-pretreated rabbits.
O
Outcome
Radioactivity of H3-epinephrine or H3-norepinephrine in plasma and urine, and H3-acidic metabolites in urine (and myocardium in rabbits).surrogate

Nitroglycerin appears to accelerate the inactivation of catecholamines, suggesting a metabolic mechanism for its anti-anginal effects beyond simple coronary vasodilation.

Limitations

  • Further investigation is necessary concerning the urine analyses.

Cite This Study

Kobayashi et al. (1966) studied this question.

synapsesocial.com/papers/6a897bfc6fc170cbc2fba75dhttps://doi.org/10.1536/ihj.7.430
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ineffectiveness of Nitroglycerin as an Antiadrenergic Agent on the Cat Heart1956 · 11 citations
  2. 2Effect of Catecholamines, l-Epinephrine and l-Norepinephrine on Coronary Flow and Oxygen Metabolism of the Myocardium1958 · 48 citations
  3. 3Transdermal nitroglycerin efficacy in patients with chronic stable angina pectoris as related to sympathetic and renin-angiotensin-aldosterone activity1992 · 13 citations
  4. 4The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans.1984 · 66 citations
  5. 5The Effect of a β-Adrenergic-Blocking Agent (Nethalide) and Nitroglycerin on Exercise Tolerance in Angina Pectoris1965 · 39 citations