Key result
In a review of 39 cases of laryngeal synovial sarcoma, no clinicopathologic factors or specific treatment regimens were associated with improved overall survival or lower rates of recurrence.
Why the study?
Primary laryngeal synovial sarcoma is extremely rare with no well-defined guidelines to direct investigation and management, leaving treatment largely based on limb synovial sarcoma.
Do specific clinicopathologic factors or treatment regimens improve overall survival or reduce recurrence in patients with primary laryngeal synovial sarcoma?
Population
39 cases of primary laryngeal synovial sarcoma from 32 studies
Design
PROSPERO-registered systematic review
Authors
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No prognostic factors or regimens improve laryngeal synovial sarcoma outcomes; leaves open standardized reporting and prospective studies to guide management.
Systematic Review (n=39)
Do specific clinicopathologic factors or treatment regimens improve overall survival or reduce recurrence in patients with primary laryngeal synovial sarcoma?
There is significant heterogeneity in the treatment of primary laryngeal synovial sarcoma, with no specific regimen showing improved survival, highlighting the need for standardized reporting and formal clinical guidelines.
Shein et al. (2019) conducted a systematic review in Primary laryngeal synovial sarcoma (n=39). Various treatments (surgical excision, radiotherapy, chemotherapy) was evaluated on Overall survival and rate of recurrence. In a review of 39 cases of laryngeal synovial sarcoma, no clinicopathologic factors or specific treatment regimens were associated with improved overall survival or lower rates of recurrence.
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