Key result
Numerical simulation of drug-eluting stents in a coronary artery model revealed complex drug concentration patterns and accumulation in the vicinity of fat buildup.
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Computational modeling of drug-eluting stents demonstrates that drug concentration patterns are complex and tend to accumulate near atherosclerotic plaques.
The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite Element Method (FEM). The dynamics of drug-eluting concentration in bloodstream was investigated using four drug-eluting stents with different mass diffusivities in microchannels with variable cross sections, including a real coronary artery geometry with atherosclerosis. The results reveal complex drug concentration patterns and accumulation in the vicinity of the fat buildup.
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Marques et al. (2021) studied Atherosclerosis. Drug-eluting stents with different mass diffusivities was evaluated on Drug concentration patterns and accumulation. Numerical simulation of drug-eluting stents in a coronary artery model revealed complex drug concentration patterns and accumulation in the vicinity of fat buildup.
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