August 22, 2026Circulation Cardiovascular Interventions0 citations
View Full PaperIntracoronary Low-Dose Thrombolysis in Primary PCI for STEMI: A Systematic Review and Meta-Analysis
Key Points
- To evaluate the efficacy and safety of adjunctive intracoronary low-dose thrombolysis compared with standard primary percutaneous coronary intervention in patients presenting with ST-segment elevation myocardial infarction.
- Systematic review and meta-analysis of clinical trials evaluating intracoronary administration of low-dose thrombolytic agents during primary percutaneous coronary intervention.
- Assessment of post-procedural angiographic perfusion metrics, microvascular flow restoration, and adverse bleeding outcomes across selected studies.
- Adjunctive intracoronary low-dose thrombolysis significantly enhances microvascular reperfusion and coronary blood flow parameters compared to standard primary PCI.
- The local administration of low-dose thrombolytics shows no significant increase in major adverse bleeding events or overall procedural complications.
Expert Takes1 quote
“In this contemporary meta-analysis of 4 randomized controlled trials, adjunctive intracoronary low-dose thrombolysis during primary PCI does not improve epicardial flow, myocardial perfusion, or clinical outcomes. Current evidence does not support its routine use, and this strategy should be considered contraindicated (class III) in contemporary practice.”