Key result
Candesartan cilexetil dose-dependently decreased systolic blood pressure by 6-12 mmHg (P=0.01) and diastolic blood pressure by 5-11 mmHg (P=0.03) at 4 weeks in hypertensive children aged 1-5 years.
Why the study?
Does candesartan cilexetil dose-dependently reduce blood pressure and albuminuria in hypertensive children aged 1-5 years?
RCT (n=93)
Double-blind
randomized
Does candesartan cilexetil dose-dependently reduce blood pressure and albuminuria in hypertensive children aged 1-5 years?
p-value: p=0.01
Candesartan cilexetil liquid suspension effectively and safely lowers blood pressure and albuminuria in a dose-dependent manner in hypertensive children aged 1 to 5 years.
Authors
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Supports candesartan for hypertension in children aged 1-5 years; extends pediatric ARB evidence to this younger population.
Schaefer et al. (2010) conducted an RCT in hypertension (n=93). candesartan cilexetil vs. Different doses (dose-ranging) was evaluated on Decline in systolic and diastolic blood pressure at 4 weeks (p=0.01). Candesartan cilexetil dose-dependently decreased systolic blood pressure by 6-12 mmHg (P=0.01) and diastolic blood pressure by 5-11 mmHg (P=0.03) at 4 weeks in hypertensive children aged 1-5 years.
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