Non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up study
Key result
Current use of NSAIDs was associated with an increased risk of atrial fibrillation compared with never-use (HR 1.76; 95% CI 1.07-2.88).
Why the study?
Does the use of NSAIDs increase the risk of atrial fibrillation in elderly individuals without prior atrial fibrillation?
Population
8,423 participants without atrial fibrillation at baseline from the population-based Rotterdam Study, mean…
Comparison
Use of non-steroidal anti-inflammatory drugs vs Never-use of NSAIDs
Design
Cohort
Follow-up
mean 12.9 years
Authors
Discussion
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Implication
May warrant caution with NSAIDs in elderly without AF; leaves open causality and needs RCT confirmation.
Study Design
Type
Cohort (n=8,423)
Structured PICO
Does the use of NSAIDs increase the risk of atrial fibrillation in elderly individuals without prior atrial fibrillation?
P
Population
8,423 elderly individuals without atrial fibrillation at baseline, followed for a mean of 12.9 years.
E
Exposure
Use of non-steroidal anti-inflammatory drugs (NSAIDs) (current or recent use)
C
Comparator
Never-use of NSAIDs
O
Outcome
Atrial fibrillation ascertained from ECG assessments and medical recordshard clinical
Main Result
Hazard Ratio: 1.76 (95% CI 1.07–2.88)
Current and recent use of NSAIDs is associated with a significantly increased risk of developing atrial fibrillation in an elderly population.
Cite This Study
Krijthe et al. (2014) conducted a cohort in Without atrial fibrillation (n=8,423). Non-steroidal anti-inflammatory drugs (NSAIDs) vs. Never-use was evaluated on Atrial fibrillation (HR 1.76, 95% CI 1.07 to 2.88). Current use of NSAIDs was associated with an increased risk of atrial fibrillation compared with never-use (HR 1.76; 95% CI 1.07-2.88).