Key result
Significant progress has been made toward understanding the structural basis of potassium channel function and associated diseases through biophysical, molecular, and structural studies.
Provides a general overview of the structural basis and function of potassium channels, as well as diseases associated with their dysfunction.
Answers are grounded in this paper and cite their sources.
May inform targeted therapies for channelopathies; extends structural insights but leaves clinical translation open.
Potassium channels are integral membrane proteins that selectively transport K/sup +/ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and mechanisms of different gating events, and the interaction of channels with a variety of accessory proteins. Through the integration of biophysical, molecular, structural, and theoretical studies, significant progress has been made toward understanding the structural basis of K/sup +/ channel function, and diseases associated with K/sup +/ channel dysfunction.
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Korn et al. (2005) conducted a review in Potassium channel dysfunction. Significant progress has been made toward understanding the structural basis of potassium channel function and associated diseases through biophysical, molecular, and structural studies.
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