Catalyst‐Controlled Stereoselective Combinatorial Synthesis

Stereochemical diversity as a novel concept in combinatorial chemistry for the synthesis of nonpeptidic biologically active compounds is introduced. As an example, the combination of the hydrogenation of imines in the presence of either enantiomer of a chiral Ru catalyst with a domino reaction led to the targeted construction of 12 of the 16 possible stereoisomers of emetine (1).