Why the study?
Does pyridostigmine improve quality of life, muscle strength, fatigue, and serum IGF-I levels in patients with postpoliomyelitis syndrome?
Population
126 patients with postpoliomyelitis syndrome (PPS)
Comparison
Pyridostigmine 60 mg three times per day for 6… vs Placebo
Design
RCT, randomized, double-blinded
Follow-up
6 months
Authors
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Pyridostigmine should not be prescribed for postpoliomyelitis syndrome; confirms lack of efficacy on primary outcomes in this RCT.
Does pyridostigmine improve quality of life, muscle strength, fatigue, and serum IGF-I levels in patients with postpoliomyelitis syndrome?
A 6-month course of pyridostigmine does not improve quality of life, muscle strength, fatigue, or IGF-I levels in patients with postpolio syndrome.
Trojan et al. (1999) studied this question.
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