May 1, 1991The Journal of PhysiologyOpen Access

Influence of pressure alterations on tone and vasomotion of isolated mesenteric small arteries of the rat.

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Population

18 isolated distal rat mesenteric arcade arteries and first-order branches

Design

Preclinical

Authors

EVEd VanBavelAmsterdam University Medical Centers MGMaurice J.M.M. GiezemanIsala TMTrudi MooijUniversity of Amsterdam

Discussion

Member takes

Implication

Does not support clinical changes in vascular tone management; leaves open translation of wall-stress mechanisms to human arteries.

Structured PICO

Population

18 isolated distal rat mesenteric arcade arteries and first-order branches

Intervention

Stepwise changes of pressure (distending pressure 40-120 mmHg) and 0.3-1 microM noradrenaline

Outcome

Luminal cross-sectional area (tone and vasomotion)surrogate

This preclinical study demonstrates that myogenic responses in small mesenteric arteries are driven by wall stress rather than distension, independent of basal tone.

Cite This Study

VanBavel et al. (1991) studied this question.

synapsesocial.com/papers/6a89876af8670bac6e33495c https://doi.org/10.1113/jphysiol.1991.sp018555

View Full Paper

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Influence of pressure alterations on tone and vasomotion of isolated mesenteric small arteries of the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of pressure alterations on tone and vasomotion of isolated mesenteric small arteries of the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider