Population
Peptides based on the N-terminal region of human cardiac troponin I
Comparison
Phosphorylation by cAMP-dependent protein kinase vs Peptides with Arg22 replaced by Ala or Met
Design
Preclinical
Authors
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May alter troponin I responsiveness to adrenergic stimuli; hypothesis-generating for contractile regulation, requires in vivo validation.
The study reveals the ordered phosphorylation of Ser24 followed by Ser23 in human cardiac troponin I by cAMP-dependent protein kinase, highlighting the structural role of the N-terminal sequence RRRSS.
Keane et al. (1997) studied this question.
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