February 1, 1974Biochemical JournalOpen Access

The interaction of the calcium-binding protein (troponin C) with bivalent cations and the inhibitory protein (troponin I)

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Population

Rabbit white skeletal muscle, red skeletal muscle, and cardiac muscle (calcium-binding protein / troponin C)

Comparison

Addition of bivalent cations and interaction… vs Ca2+-free form and other bivalent metal ions

Design

Preclinical

Authors

JHJ. W. HeadRutgers, The State University of New Jersey SPS V PerryUniversity of California, Los Angeles

Discussion

Member takes

Implication

Reveals Ca2+-dependent troponin interactions in vitro; leaves open translation to human cardiac physiology and therapeutics.

Structured PICO

Population

Rabbit white skeletal muscle, red skeletal muscle, and cardiac muscle (calcium-binding protein / troponin C)

Intervention

Addition of bivalent cations (Ca2+, Cd2+, Mg2+) and interaction with inhibitory protein (troponin I)

Comparator

Ca2+-free form and other bivalent metal ions

Outcome

Conformational changes, molecular weight estimation, and complex formationsurrogate

This basic science study characterizes the biochemical properties of troponin C, its interaction with calcium, and its complex formation with troponin I in rabbit muscle.

Cite This Study

Head et al. (1974) studied this question.

synapsesocial.com/papers/6a202dbe6ed993cb49fbffd8 https://doi.org/10.1042/bj1370145

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The interaction of the calcium-binding protein (troponin C) with bivalent cations and the inhibitory protein (troponin I)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The interaction of the calcium-binding protein (troponin C) with bivalent cations and the inhibitory protein (troponin I)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider