Noncovalent Modification of Chromatin: Different Remodeled Products with Different ATPase Domains

The ability to maintain the same master regulatorygene in an "on" state in one cell lineage and in an "off"state in another cell lineage is fundamental to proper development. There is general agreement that modificationof chromatin structure can contribute to this form of epigenetic regulation. Thus, a locus that must be repressed ina heritable fashion might have a specialized chromatinstructure that is repressive to transcription, and the samelocus in another cell lineage where it is heritably activemight have a permissive chromatin structure...