What question did this study set out to answer?

To examine the anabolic effects of beta-cryptoxanthin isolated from Satsuma mandarin on femoral bone components in vitro and in vivo in rats.

January 1, 2004Biological and Pharmaceutical BulletinOpen Access

Oral Administration of .BETA.-Cryptoxanthin Induces Anabolic Effects on Bone Components in the Femoral Tissues of Rats in Vivo

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Authors

SUSatoshi UchiyamaNational Cancer Center Hospital East TSTakashi SumidaNihon University MYMasayoshi YamaguchiUniversity of Hawaiʻi at Mānoa

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Implication

Animal study demonstrates anabolic effects of beta-cryptoxanthin on bone components in young male rats, indicating potential dietary strategies for enhancing bone health.

Key Points

To examine the anabolic effects of beta-cryptoxanthin isolated from Satsuma mandarin on femoral bone components in vitro and in vivo in rats.
Cultured rat femoral-diaphyseal and metaphyseal tissues for 48 hours in serum-free medium containing vehicle or beta-cryptoxanthin (10^-7 or 10^-6 M), with or without the protein synthesis inhibitor cycloheximide (10^-6 M).
Orally administered beta-cryptoxanthin (10, 25, or 50 µg/100 g body weight) once daily for 7 days to young male rats.
Assessed bone calcium content, alkaline phosphatase activity, and DNA content in femoral-diaphyseal and femoral-metaphyseal tissues.
In vitro culture with beta-cryptoxanthin (10^-7 or 10^-6 M) significantly increased calcium content and alkaline phosphatase activity in femoral tissues, which was completely abolished by cycloheximide.
Oral administration of beta-cryptoxanthin at 10, 25, or 50 µg/100 g body weight significantly increased calcium content and alkaline phosphatase activity in diaphyseal and metaphyseal tissues.
Oral doses of 25 and 50 µg/100 g significantly increased DNA content in both femoral regions, whereas the 10 µg/100 g dose significantly increased metaphyseal DNA content.

Cite This Study

Uchiyama et al. (2004) studied this question.

synapsesocial.com/papers/6a898c351fb56efa37d45910 https://doi.org/10.1248/bpb.27.232

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Implication

Animal study demonstrates anabolic effects of beta-cryptoxanthin on bone components in young male rats, indicating potential dietary strategies for enhancing bone health.

Oral Administration of .BETA.-Cryptoxanthin Induces Anabolic Effects on Bone Components in the Femoral Tissues of Rats in Vivo

Discussion

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Implication

Key Points

Cite This Study

Oral Administration of .BETA.-Cryptoxanthin Induces Anabolic Effects on Bone Components in the Femoral Tissues of Rats in Vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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