Key result
Poor sleep quality was significantly associated with an increased risk of mild cognitive impairment (OR 1.307) in older adults with multimorbidity, with a threshold effect at a PSQI score of 12.
Why the study?
To explore the relationship between sleep quality and mild cognitive impairment in older adult patients with multimorbidity.
Is poor sleep quality associated with an increased risk of mild cognitive impairment in older adult patients with multimorbidity?
Cross-Sectional (n=902)
Yes
Is poor sleep quality associated with an increased risk of mild cognitive impairment in older adult patients with multimorbidity?
Odds Ratio: 1.307 (95% CI 1.172–1.458)
p-value: p=<0.001
Poor sleep quality is non-linearly associated with an increased risk of mild cognitive impairment in older adults with multimorbidity, with a significant risk increase when the PSQI score reaches 12.
Poorer sleep quality was associated with MCI in multimorbid elders; hypothesis-generating and leaves open causal role or intervention effects.
Objective: To explore the relationship between sleep quality and mild cognitive impairment in older adult patients with multimorbidity. Methods: The general data of older adult patients with chronic diseases were collected, and the sleep quality and mild cognitive impairment (MCI) of older adult patients with multimorbidity were investigated by questionnaire. Logistic regression model and restricted cubic spline (RCS) model were used to analyze the correlation between sleep quality and MCI in older adult patients with multimorbidity. Results: There are 902 valid samples in this study, of which 333 (36.9%) have MCI. The number of chronic diseases ranges from 2 to 6, and the number of types of medication ranges from 0 to 7. The score of PSQI is 2-18, with an average score of 11.13. MoCA score range is 7-30. The MoCA score of MCI patients is lower than that of Non-MCI patients. In all three models, PSQI score is significantly correlated with MCI. The results of the segmented regression analysis show that: the inflection point of MCI's PSQI scoring relationship is 12. RCS result display: with the increase of PSQI score, the OR increases between PSQI score and MCI, when PSQI score reaches 12, OR is significantly higher than 1. Conclusion: Sleep quality is an important influencing factor of MCI, and there is a threshold effect in the above association. According to this correlation, health professionals can take measures to improve the sleep quality of older adult patients with multimorbidity to reduce the occurrence of MCI.
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Yang et al. (2025) conducted a cross-sectional in Mild cognitive impairment in multimorbidity (n=902). Poor sleep quality (PSQI score) vs. Better sleep quality (lower PSQI score) was evaluated on Mild cognitive impairment (MCI) (OR 1.307, 95% CI 1.172-1.458, p=<0.001). Poor sleep quality was significantly associated with an increased risk of mild cognitive impairment (OR 1.307) in older adults with multimorbidity, with a threshold effect at a PSQI score of 12.
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