Why the study?
Does growth hormone from GH-secreting tumors increase T-type calcium current in cardiac myocytes of adult rats?
Population
Adult female Wistar-Furth rats (3 months old) and isolated atrial and ventricular myocytes.
Comparison
Induction of growth hormone-secreting tumors via… vs Untreated, age-matched control animals.
Design
Preclinical
Follow-up
8 weeks
Authors
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Suggests GH-linked atrial ion channel remodeling in rats; leaves open relevance to human arrhythmia or hypertrophy risk.
Does growth hormone from GH-secreting tumors increase T-type calcium current in cardiac myocytes of adult rats?
Growth hormone-secreting tumors induce a specific, 3-fold enhancement of T-type calcium current in adult rat atrial myocytes that precedes measurable cardiac hypertrophy.
Xu et al. (1990) studied this question.
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