Antinuclear Factors in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Article1 July 1965Antinuclear Factors in Systemic Lupus Erythematosus and Rheumatoid ArthritisEUGENE V. BARNETT, M.D., A. FREDERICK NORTH JR., M.D., JOHN J. CONDEMI, M.D., RALPH F. JACOX, M.D., JOHN H. VAUGHAN, M.D.EUGENE V. BARNETT, M.D.Search for more papers by this author, A. FREDERICK NORTH JR., M.D.Search for more papers by this author, JOHN J. CONDEMI, M.D.Search for more papers by this author, RALPH F. JACOX, M.D.Search for more papers by this author, JOHN H. VAUGHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-100 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiscovery of the lupus erythematosus (LE) cell phenomenon in 1948 by Hargraves, Richmond, and Morton (1) was the first of a series of observations of what have proved to be immunologic phenomena in systemic lupus erythematosus (SLE). In 1950 the serum factor essential for the production of LE cells was identified as a gamma globulin (2). Subsequently the LE cell phenomenon was demonstrated to involve the reaction of white blood cell nucleoprotein (3) and antibody contained in the gamma globulin fraction of SLE sera (4). Several investigators (5, 6-8), utilizing immunofluorescence techniques, detected antinuclear factors in SLE sera capable of...References1. HARGRAVESRICHMONDMORTON MMHR: Presentation of two bone marrow elements "tart" cell and "L.E." cell. Proc. Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar2. HASERICKLEWISBORTZ JRLADW: Blood factor in acute disseminated lupus erythematosus. I. Determination of gamma globulin as specific plasma fraction. Amer. J. Med. Sci. 219: 660, 1950. CrossrefMedlineGoogle Scholar3. HOLMANDEICHER HRHR: The reaction of the L.E. cell factor with deoxyribonucleoprotein of the cell nucleus. J. Clin. Invest. 38: 2059, 1959. CrossrefMedlineGoogle Scholar4. 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Electrophoretic, ultracentrifugal, and chromatographic studies. J. Clin. Invest. 39: 1595, 1960. CrossrefMedlineGoogle Scholar10. ENGELFRIETVANDERHARTVANLOGHEM CMJ: The use of chicken red cells in the Coombs' Consumption Test as a specific and simple method for the detection of the L.E. factor. Vox Sang. 4: 485, 1959. CrossrefMedlineGoogle Scholar11. PEARSONCRADDOCKSIMMONS CMCGNS: Complement fixation with DNA and leukocyte material in SLE. Correlation with LE cell phenomenon and the clinical status. J. Lab. Clin. Med. 52: 580, 1958. MedlineGoogle Scholar12. DEICHERHOLMANKUNKEL HRHRHG: The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus. J. Exp. Med. 109: 97, 1959. CrossrefMedlineGoogle Scholar13. KAYOENASOUBOZICEVICH DEJPJ: Clinical evaluation of the DNA bentonite flocculation test for SLE. New Eng. J. Med. 263: 5, 1960. CrossrefMedlineGoogle Scholar14. DEICHERHOLMANKUNKELOVARY HHHL: PCA caused by the reaction of SLE serum with DNA. J. Immun. 84: 106, 1960. MedlineGoogle Scholar15. SCALETTARMARCUSSIMONTONMUSCELL RDLL: The nucleoprotein complementfixation test in the diagnosis of systemic lupus erythematosus. New Eng. J. Med. 263: 226, 1960. CrossrefMedlineGoogle Scholar16. ATCHLEY WA: An immunoelectrophoretic analysis of antigens reacting with lupus serum. Arthritis Rheum. 5: 471, 1961. CrossrefGoogle Scholar17. STURGILLCARPENTERSTRAUSSGOODMAN BCRRAJHC: Antibodies in systemic lupus erythematosus and myasthenia gravis which react with thermally denatured DNA-coated bentonite. Proc. Soc. Exp. Biol. Med. 115: 246, 1964. CrossrefMedlineGoogle Scholar18. CEPPILLINIDRAYEDELMAN RSG: Nomenclature for human immunoglobulins. Bull. WHO 30: 447, 1964. MedlineGoogle Scholar19. BAUERMATHIESSTAVITSKY DCMJAB: Sequences of synthesis of gamma1 macroglobulin and gamma2 globulin antibodies during primary and secondary responses to proteins, Salmonella antigens, and phage. J. Exp. Med. 117: 889, 1963. CrossrefMedlineGoogle Scholar20. 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BARNETTCONDEMILEDDYVAUGHAN EVJJJPJH: Gamma2, gamma1A, and gamma1M antinuclear factors in human sera. J. Clin. Invest. 43: 1104, 1964. CrossrefMedlineGoogle Scholar26. HIJMANSSCHUITMANDEMANIEHNUISKELTKAMPHOLBOROWJOHNSON WHRERLTEEJGD: Comparative study for the detection of ANF with the fluorescent antibody technique. Ann. Rheum. Dis. 23: 73, 1964. CrossrefMedlineGoogle Scholar27. SINGERPLOTZ JMCM: The latex fixation test. I. Application to serologic diagnosis of rheumatoid arthritis. Amer. J. Med. 21: 888, 1956. CrossrefMedlineGoogle Scholar28. HARVEY AM: Auto-immune disease and the chronic biologic false-positive test for syphilis. JAMA 182: 115, 1962. CrossrefGoogle Scholar29. MANDEMAPALLOCKKARKREZAIAN EVRJ: Quantitative observations on antinuclear factors in systemic lupus erythematosus. J. Lab. Clin. Med. 58: 337, 1961. MedlineGoogle Scholar30. CONDEMIBARNETTATWATERJACOXVAUGHAN JJEVECRFJH: The significance of anti-nuclear factors in rheumatoid arthritis. 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HOLMANDEICHERKUNKEL HRHRHG: The L.E. cell and the L.E. serum factors. Bull. N. Y. Acad. Med. 35: 409, 1959. MedlineGoogle Scholar38. WILKENSDECKER RFJL: Rheumatoid arthritis with serologic evidence suggesting systemic lupus erythematosus; clinical, serologic chromatographic studies. Arthritis Rheum. 6: 720, 1963. CrossrefMedlineGoogle Scholar39. BARNETTBAKEMEIERLEDDYVAUGHAN EVRFJPJH: Heterogeneity of antinuclear factors in lupus erythematosus and rheumatoid arthritis. Proc. Soc. Exp. Biol. Med. 118: 803, 1965. CrossrefMedlineGoogle Scholar40. BARNETTVAUGHAN EVJH: Antinuclear factors in rabbit sera. Fed. Proc. April, 1965. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EUGENE V. BARNETT, M.D.; A. FREDERICK NORTHJR., M.D.; JOHN J. CONDEMI, M.D.; RALPH F. JACOX, M.D.; JOHN H. VAUGHAN, M.D.Affiliations: Rochester, New YorkFrom the Departments of Medicine and Pediatrics, University of Rochester School of Medicine and Dentistry, Strong Memorial and Rochester General Hospitals, Rochester, N. Y.This study was supported by research grants from the National Institutes of Health, Bethesda, Md., and the National Foundation, New York, N. Y.Portions of this study were presented before the Second Fall Meeting of the American College of Physicians, Los Angeles, Calif., October 10, 1964.Requests for reprints should be addressed to Eugene V. Barnett, M.D., Department of Medicine, the Center for the Health Sciences, University of California, Los Angeles, Calif. 90024. 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NEBLETT, M.B., PH.D. 1 July 1965Volume 63, Issue 1Page: 100-108KeywordsAntigensArthritisGlobulinsImmunofluorescenceLupus erythematosusNeutrophilsPediatricsResearch grantsRheumatoid arthritisWhite blood cells ePublished: 1 December 2008 Issue Published: 1 July 1965 PDF downloadLoading ...