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November 1, 2024JACC: Cardiovascular InterventionsOpen Access

M-TEER in patients with secondary mitral regurgitation was associated with a 5-year survival of 35.0% and sustained MR reduction to grade ≤2+ in 85.5% of patients.

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Why the study?

Long-term outcome data after mitral valve transcatheter edge-to-edge repair (M-TEER) for secondary mitral regurgitation under real-world conditions were lacking.

Population

1,628 patients with significant secondary MR undergoing M-TEER from the EuroSMR registry

Comparison

M-TEER outcomes across degrees of residual MR

Design

Multicenter registry study

Follow-up

5 years

Key result

M-TEER in patients with secondary mitral regurgitation was associated with a 5-year survival of 35.0% and sustained MR reduction to grade ≤2+ in 85.5% of patients.

Authors

TSThomas J. StockerLSLukas StolzNKNicole Karam

Discussion

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Member takes

Overview

Sustained MR reduction and NYHA improvement at 5 years support durability in real-world practice; leaves open survival benefit versus medical therapy in broader populations.

Study Design

Type

Cohort (n=1,628)

Multicenter

Yes

Structured PICO

P
Population
1,628 patients (mean age 73.8 years) with significant secondary mitral regurgitation undergoing M-TEER, followed for 5 years.
E
Exposure
Mitral valve transcatheter edge-to-edge repair (M-TEER)
O
Outcome
Long-term MR reduction, functional outcomes, survival rate, and predictors for all-cause mortality at 5 yearshard clinical

In a large real-world registry, M-TEER provided durable long-term MR reduction and functional improvement in patients with secondary MR, with 5-year survival strongly associated with the degree of residual MR.

Cite This Study

Stocker et al. (2024) conducted a cohort in Secondary mitral regurgitation (n=1,628). Mitral valve transcatheter edge-to-edge repair (M-TEER) was evaluated on 5-year survival. M-TEER in patients with secondary mitral regurgitation was associated with a 5-year survival of 35.0% and sustained MR reduction to grade ≤2+ in 85.5% of patients.

synapsesocial.com/papers/6a898e8dde8e7079c6f7d74fhttps://doi.org/10.1016/j.jcin.2024.08.016
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