Key result
Implantation of the MitraClip G4 NTW device in a single patient resulted in significant mitral regurgitation reduction with a 57% reduction in mitral valve area.
Why the study?
Does the MitraClip G4 NTW device reduce mitral regurgitation in a patient with severe degenerative MR and a small mitral valve area?
Case Report (n=1)
Does the MitraClip G4 NTW device reduce mitral regurgitation in a patient with severe degenerative MR and a small mitral valve area?
This first-in-human report demonstrates the feasibility and efficacy of the MitraClip G4 NTW device for treating severe degenerative mitral regurgitation in a patient with a small mitral valve area.
May support use in small mitral valve area; leaves open safety and durability in larger cohorts.
The new MitraClip G4 device (Abbott Vascular) has been recently approved by Food and Drug Administration and is currently in limited release. A patient with a large mitral regurgitation (MR) jet but a relatively small mitral valve area (MVA) was not a surgical repair candidate nor an optimal MitraClip third-generation device candidate. Therefore, we implanted the new G4 NTW device that resulted in significant MR reduction with a 57% reduction in MVA. To our knowledge, this is the first reported clinical use of the MitraClip G4 NTW device. We find that it may provide better results than a single NTR device and less reduction in MVA than two older generation devices. Further experience is needed to optimize patient selection for the four new G4 devices available.
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Raghunathan et al. (2020) conducted a case report in Severe degenerative mitral regurgitation (n=1). MitraClip G4 NTW device was evaluated on Mitral regurgitation (MR) and mitral valve area (MVA) reduction. Implantation of the MitraClip G4 NTW device in a single patient resulted in significant mitral regurgitation reduction with a 57% reduction in mitral valve area.
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