L-3,5,3'-triiodothyronine (L-TRITh) was detected in blood almost simultaneously by Gross & Pitt-Rivers (1952) and by Roche et al. (1952). It is present in serum together with the other thyroid hormone, L-thyroxine, there being up to 7 or 10 parts L-TRITh-iodine per 100 parts L-thyroxine-iodine (Brown & Jackson, 1954, Critchlow & Goldfinch, 1954, Gross & Pitt-Rivers, 1952, Pitt-Rivers et al., 1955, Roche et al., 1952). Some authors have not been able to trace TRITh in serum (Albright et al., 1953). Intake of L-TRITh or L-thyroxine increases the oxygen consumption. the effect of L-TRITh reaches a maximum within one or two days, but that of L-thyroxine does not reach maximum until after 6 or 8 days' continuous intake. the increase of oxygen consumption caused by L-TRITh has been found to be up to 5 times greater than that due to L-thyroxine. Several methods for the chemical determination of TRITh in serum have
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K. Pind (1957) studied this question.