Key result
Quantitative results comparing electrocardiographic imaging findings between patients with mitral regurgitation and healthy controls were not reported in the truncated abstract.
Why the study?
Patients with MR often develop AF, but the underlying electrophysiological mechanism is poorly understood.
Does electrocardiographic imaging identify alterations in the electrophysiological substrate in patients with mitral regurgitation that may contribute to atrial fibrillation?
Observational (n=61)
Does electrocardiographic imaging identify alterations in the electrophysiological substrate in patients with mitral regurgitation that may contribute to atrial fibrillation?
Electrocardiographic imaging can be used to non-invasively map atrial activation in patients with mitral regurgitation to identify electrophysiological substrates for atrial fibrillation.
Altered atrial activation patterns in MR may promote AF; hypothesis-generating and should not yet change practice.
mitral regurgitation; atrial fibrillation Patients with mitral regurgitation (MR) often develop atrial fibrillation (AF), which increases morbidity and mortality.The mechanism underlying this is poorly understood.This study used electrocardiographic imaging (ECGI) to map atrial activation in patients with MR with and without AF during sinus rhythm (SR).The aim was to identify alterations in the electrophysiological substrate that may contribute to AF.We previously published a subset of these data but have expanded the cohort and added a control group. 1 The protocol was approved by the Washington University Institutional Review Board.Participants provided informed consent.The data are available from the corresponding author upon reasonable request.Sixty-one participants were enrolled: 21 with MR and a history of AF (MR+AF), 25 with MR alone, and 15 volunteers of similar age with no cardiac disease (control).Twenty of these subjects (11 MR, 9 MR+AF) were included in our previous report. 1No subject had coronary artery disease, other valvular heart disease, previous cardiac surgery, or catheter ablation.MR and left ventricular ejection fraction (EF) were quantified by review of echocardiography reports.Body surface potentials were recorded using the ActiveTwo system (Biosemi, Amsterdam, Netherlands).CT or MRI images were used to create models of the heart and body surface, and ECGI was performed using custom MATLAB scripts. 2 Biatrial activation maps were created, and conduction times and electrogram amplitudes were analyzed, 1 as was
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Schill et al. (2024) conducted an observational in Mitral regurgitation and atrial fibrillation (n=61). Mitral regurgitation with or without atrial fibrillation vs. Healthy volunteers with no cardiac disease was evaluated. Quantitative results comparing electrocardiographic imaging findings between patients with mitral regurgitation and healthy controls were not reported in the truncated abstract.
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