What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin-induced cardiotoxicity (n=32). Intervention: Melatonin and Thymoquinone vs. Doxorubicin alone. Primary outcome: QTc interval (sec) (p=<0.05).

January 1, 2020Bratislavské lekárske listy/Bratislava medical journalOpen Access

The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats

Q: What are the key findings of this study?

Melatonin significantly improved histological damage and biochemical parameters, while thymoquinone significantly improved ECG parameters including QTc interval in rats with doxorubicin-induced cardiotoxicity.

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Key result

Melatonin significantly improved histological damage and biochemical parameters, while thymoquinone significantly improved ECG parameters including QTc interval in rats with doxorubicin-induced cardiotoxicity.

Why the study?

Melatonin and thymoquinone may play an important role in cardiotoxicity, prompting investigation into their potential protective effects against doxorubicin-induced cardiotoxicity in rats.

Do melatonin and thymoquinone prevent doxorubicin-induced cardiotoxicity in rats?

Population

Rats

Comparison

Control vs DXR vs DXR+melatonin vs DXR+thymoquinone

Design

Preclinical animal study

Follow-up

8 days

Authors

DPDeniz YILDIZ PEHLİVAN GDGülçin Durdağı EOEser Öz OyarIzmir Kâtip Çelebi University

Discussion

Member takes

Overview

Should not yet change clinical practice; hypothesis-generating for human doxorubicin cardiotoxicity prevention.

Structured PICO

Do melatonin and thymoquinone prevent doxorubicin-induced cardiotoxicity in rats?

Population

32 male Wistar albino rats weighing 230-350 g, subjected to doxorubicin-induced cardiotoxicity and treated for 7 days.

Intervention

Melatonin (10 mg/kg/day intraperitoneally for 7 days) or Thymoquinone (50 mg/kg/day orally for 7 days) plus Doxorubicin (45 mg/kg IV on 5th day)

Comparator

Doxorubicin alone (45 mg/kg IV on 5th day) and Control (physiological serum IV on 5th day)

Outcome

ECG parameters (RR, PR, QRS, QT, QTc intervals), histopathological left ventricular injury scores, and biochemical markers (CK-MB, interleukins, MDA, NO, SOD) at day 8surrogate

Main Result

Absolute Event Rate: 0.217% vs 0.25%

p-value: p=<0.05

In a rat model of doxorubicin-induced cardiotoxicity, melatonin provided histological and biochemical protection, whereas thymoquinone primarily improved electrocardiographic parameters.

Limitations

Animal model results may not directly translate to human clinical outcomes
Some animals died during the experiment due to doxorubicin toxicity and were excluded
Further studies are needed to investigate the cardioprotective effect of thymoquinone with regard to optimal dosages and treatment durations
Further studies are needed to investigate the cardioprotective effect of thymoquinone with regard to dosages and treatment durations.

Cite This Study

PEHLİVAN et al. (2020) studied Doxorubicin-induced cardiotoxicity (n=32). Melatonin and Thymoquinone vs. Doxorubicin alone was evaluated on QTc interval (sec) (p=<0.05). Melatonin significantly improved histological damage and biochemical parameters, while thymoquinone significantly improved ECG parameters including QTc interval in rats with doxorubicin-induced cardiotoxicity.

synapsesocial.com/papers/6a8991e3a4df84145ecb17cb https://doi.org/10.4149/bll_2020_123

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January 1, 2020Bratislavské lekárske listy/Bratislava medical journalOpen Access

The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Melatonin and thymoquinone may play an important role in cardiotoxicity, prompting investigation into their potential protective effects against doxorubicin-induced cardiotoxicity in rats.

Do melatonin and thymoquinone prevent doxorubicin-induced cardiotoxicity in rats?

Population

Rats

Comparison

Control vs DXR vs DXR+melatonin vs DXR+thymoquinone

Design

Preclinical animal study

Follow-up

8 days

Authors

DPDeniz YILDIZ PEHLİVAN GDGülçin Durdağı EOEser Öz OyarIzmir Kâtip Çelebi University

Discussion

Member takes

Overview

Should not yet change clinical practice; hypothesis-generating for human doxorubicin cardiotoxicity prevention.

Structured PICO

Do melatonin and thymoquinone prevent doxorubicin-induced cardiotoxicity in rats?

Population

32 male Wistar albino rats weighing 230-350 g, subjected to doxorubicin-induced cardiotoxicity and treated for 7 days.

Intervention

Melatonin (10 mg/kg/day intraperitoneally for 7 days) or Thymoquinone (50 mg/kg/day orally for 7 days) plus Doxorubicin (45 mg/kg IV on 5th day)

Comparator

Doxorubicin alone (45 mg/kg IV on 5th day) and Control (physiological serum IV on 5th day)

Outcome

ECG parameters (RR, PR, QRS, QT, QTc intervals), histopathological left ventricular injury scores, and biochemical markers (CK-MB, interleukins, MDA, NO, SOD) at day 8surrogate

Main Result

Absolute Event Rate: 0.217% vs 0.25%

p-value: p=<0.05

In a rat model of doxorubicin-induced cardiotoxicity, melatonin provided histological and biochemical protection, whereas thymoquinone primarily improved electrocardiographic parameters.

Limitations

Animal model results may not directly translate to human clinical outcomes
Some animals died during the experiment due to doxorubicin toxicity and were excluded
Further studies are needed to investigate the cardioprotective effect of thymoquinone with regard to optimal dosages and treatment durations
Further studies are needed to investigate the cardioprotective effect of thymoquinone with regard to dosages and treatment durations.

Cite This Study

synapsesocial.com/papers/6a8991e3a4df84145ecb17cb https://doi.org/10.4149/bll_2020_123

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