Key result
Severe oxygen desaturation (≥30 events/h) was associated with significantly higher 24-hour systolic blood pressure (134.9 mm Hg) compared to normal oxygen desaturation (126.2 mm Hg), an association partially mediated by pulse rate.
Cross-Sectional (n=2,342)
No
Absolute Event Rate: 134.9% vs 126.2%
p-value: p=<0.0001
Nocturnal oxygen desaturation is positively associated with ambulatory blood pressure, an effect that is partially mediated by pulse rate and is more prominent in younger males.
Severe desaturation may raise ambulatory SBP via pulse rate; hypothesis-generating and requires prospective trials before practice implications.
We investigated the relationship between ambulatory blood pressure (BP) and oxygen desaturation index (ODI), while accounting for pulse rate and age. ODI was assessed by overnight finger pulse oximetry in 2342 participants on the day of ambulatory BP monitoring, and calculated as the number of desaturation episodes per sleeping hour. Both BP and pulse rate increased significantly (P ≤ .006) from normal (< 5 events/h) to mildly (5-14), moderately (15-30), and severely (≥ 30 events/h) elevated ODI. The association for BP was substantially attenuated by accounting for pulse rate (partial r² from .003-.012 to .002-.006). In adjusted analysis, the associations of 24-hour diastolic BP and 24-hour pulse rate with ODI were dependent on age (P ≤ .0001) and only significant in younger subjects (< 60 years, P ≤ .0001). In conclusion, the association between ambulatory BP and ODI was partially mediated by pulse rate, a measure of sympathetic activity, and was more prominent in younger subjects.
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Chen et al. (2018) conducted a cross-sectional in Hypertension (established or suspected) (n=2,342). Oxygen desaturation index (ODI) vs. Normal ODI (< 5 events/h) was evaluated on 24-hour systolic blood pressure (p=<0.0001). Severe oxygen desaturation (≥30 events/h) was associated with significantly higher 24-hour systolic blood pressure (134.9 mm Hg) compared to normal oxygen desaturation (126.2 mm Hg), an association partially mediated by pulse rate.
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