Intrathecal Gentamicin

Letters, Comments, and Corrections1 December 1972Intrathecal GentamicinJERRY SMILACK, M.D., RICHARD V. MCCLOSKEY, M.D.JERRY SMILACK, M.D.Search for more papers by this author, RICHARD V. MCCLOSKEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-6-1002_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The review of treatment of Gram-negative bacillary meningitis in adults, by Rahal (Ann Intern Med 77:295-302, 1972), was a welcome addition to the medical literature. Dr. Rahal's comments on the intrathecal use of gentamicin prompt us to report our serendipitous experience with intrathecal administration of gentamicin in dosage generally considered far in excess of that recommended.We recently saw a patient who developed an acute bacterial meningitis after a basilar skull fracture and "prophylactic" antibiotic therapy with ampicillin and kanamycin.A Gram-negative bacterial infection was presumed, and treatment with cephalothin and gentamicin was started. When the causative...References1. WATANAKUNAKORN C: Penicillin combined with gentamicin or streptomycin: synergism against enterococci. J Infect Dis 124:581-586, 1971 CrossrefMedlineGoogle Scholar2. MOELLERING R, WENNERSTEN C, and WEINBERG A: Synergy of penicillin and gentamicin against enterococci. J Infect Dis 124(suppl):S207-S209, 1971 CrossrefMedlineGoogle Scholar3. RIFF L and JACKSON G: Pharmacology of gentamicin in man. Ibid., pp. S98-S105 Google Scholar4. MCCRACKEN G, CHRANE D, and THOMAS M: Pharmacologic evaluation of gentamicin in newborn infants. Ibid., pp. S214-S223 Google Scholar5. MCCRACKEN G: Discussion on gentamicin in pediatrics. Ibid., p. S259 Google Scholar6. NEWMAN R and HOLT R: Gentamicin in infections of the central nervous system. J Infect Dis 119:471-475, 1969 CrossrefMedlineGoogle Scholar7. LEEDOM J, WEHRLE P, and MATHIES A: Gentamicin in the treatment of meningitis in neonates. Ibid., pp. 476-480 Google Scholar8. NEWMAN R and HOLT R: Gentamicin in pediatrics. I. Report on intrathecal gentamicin. J Infect Dis 124(suppl) :S254-S256, 1971 CrossrefMedlineGoogle Scholar9. LERNER A: Discussion of gentamicin therapy of a paracolobactrum epidural abscess and meningitis. J Infect Dis 119:481-482, 1969 Google Scholar10. MCHENRY M, DOHN D, and TINGWALD F: Meningitis due to Escherichia coli. JAMA 212:156-158, 1970 CrossrefMedlineGoogle Scholar11. SCHEIDEMANDEL V, CAMPBELL C, and CURTIN J: Escherichia coli meningitis—treatment with gentamicin sulfate. Med Ann DC 40:85-87, 1971 MedlineGoogle Scholar12. FASANO V, NIVOLI G, and RICCARDINO N: La gentamicina nel trattamento delle infezioni in neurochirurgia. Minerva Med 58:4213-4226, 1967 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JERRY SMILACK, M.D.; RICHARD V. MCCLOSKEY, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVancomycin-resistant enterococcal meningitis treated with intrathecal streptomycinEnterococcal MeningitisIntrathecal Quinupristin/Dalfopristin for Resistant Enterococcal MeningitisNeurologische Komplikationen nach intrathekaler Applikation von MedikamentenHost Defense and Antimicrobial Therapy in Adult Gram-Negative Bacillary MeningitisJAMES J. RAHAL, M.D., MICHAEL S. SIMBERKOFF, M.D.Streptococcus Faecalis Meningitis: A Salutary CaseOtotoxicity of Intracisternal Gentamicin in CatsGentamicin in ophthalmologyCombined Intrathecal and Intramuscular Gentamicin for Gram-Negative Meningitis 1 December 1972Volume 77, Issue 6 Page: 1002-1003 Keywords Antibiotics Bacterial meningitis Gram negative bacterial infections Meningitis Skull ePublished: 1 December 2008 Issue Published: 1 December 1972 PDF downloadLoading ...